Synthesis and thermal cyclization of an enediyne-sulfonamide |
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Authors: | Michael Klein |
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Affiliation: | Institut für Organische Chemie, Universität Regensburg, D-93040 Regensburg, Germany |
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Abstract: | The synthesis of an enediyne sulfonamide by alkylidene carbene rearrangement is reported. The compound cyclizes thermally to give the Bergman product, which was prepared independently for comparison. Like other σ-acceptor substituents at the enediyne alkyne termini, such as fluoride, oxonium or ammonium groups, the sulfonamide moiety enhances the reactivity for thermal Bergman cyclization as shown by the cyclization kinetic of the title compound. |
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Keywords: | Enediyne Yne-amine Carbene rearrangement Thermal cyclization |
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