Transketolase and fructose-1,6-bis-phosphate aldolase, complementary tools for access to new ulosonic acid analogues |
| |
Authors: | Dominique Crestia |
| |
Institution: | Laboratoire de Synthèse et Etude de Systèmes à Intérêt Biologique, UMR 6504 du CNRS, Université Blaise Pascal, 63177 Aubière Cedex, France |
| |
Abstract: | A new approach to the synthesis of ulosonic acids KDO and DAH is described. The key step is the C5-C6 bond formation catalysed by fructose-1,6-bisphosphate aldolase (for KDO) or transketolase (for DAH) using substituted acrylonitrile α-hydroxyaldehyde. All asymmetric carbon configurations are determined in an enzymatic step by the means of deshydrogenase or lipase. This strategy, using a non-metabolism pathway, allows access to novel precursors of KDO, DAH and analogues. |
| |
Keywords: | C-C bond Aldolase Transketolase KDO DAH Polyol dehydrogenase |
本文献已被 ScienceDirect 等数据库收录! |
|