Assessment of Oxidative Stress in Patients with an Isolated Traumatic Brain Injury Using Disposable Electrochemical Test Strips |
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| Authors: | Leonard T Rael Raphael Bar‐Or Michael T Kelly Matthew M Carrick David Bar‐Or |
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| Institution: | 1. Swedish Medical Center, Trauma Research Department, 501 E. Hampden Ave., Room 4‐454, Englewood, CO 80113 USA phone: +1.303.788.4089;2. fax: +1.303.788.4064;3. St. Anthony Hospital, Lakewood, CO, USA;4. The Medical Center of Plano, Plano, TX, USA;5. Aytu BioScience Inc. Englewood, CO, USA;6. Princeton University, Princeton, NJ, USA |
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| Abstract: | The barriers to using plasma redox potential as a measure of oxidative stress in patients are the use of specialized equipment, necessity of sterilization between tests, and inconsistent electrode surfaces and cell geometry. These problems are resolved using disposable test strips with built in electrochemical cells. Measuring the electrode potential at a small current yields a stable value that is ～50 mV higher for isolated traumatic brain injury (ITBI) patients than for healthy individuals. Even with natural variations within blood chemistry, this simple method may be clinically useful for assessing the degree of oxidative stress and injury severity in ITBI patients. |
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| Keywords: | Isolated traumatic brain injury Oxidative stress Human plasma Redox chemistry Sensors |
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