Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating |
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| Authors: | Jia Cheng-Sheng Zhang Ze Tu Shu-Jiang Wang Guan-Wu |
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| Affiliation: | Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China. |
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| Abstract: | A rapid and efficient method for the preparation of various poly-substituted quinolines has been developed through the Friedl?nder condensation of 2-aminoarylketone or 2-aminoarylaldehyde with carbonyl compounds in the presence of p-toluene sulphonic acid, which was achieved by both microwave irradiation and conventional heating under solvent-free conditions. |
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