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Synthesis of amorpha-4,11-diene from dihydroartemisinic acid |
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| Authors: | Geoffrey Schwertz Andrea Zanetti Marllon Nascimento de Oliveira Mario Andrès Gomez Fernandez Fabienne Dioury Janine Cossy Zacharias Amara |
| Affiliation: | 1. Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI ParisTech/CNRS/PSL Research University, Paris Cedex 05, France;2. Equipe de Chimie Moléculaire, Laboratoire GBCM, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, 2 rue Conté, 75003, Paris, France |
| Abstract: | Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography. |
| Keywords: | Amorphadiene Artemisinin Malaria Elimination Microwaves |
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