Antimicrobial Depsides Produced by Cladosporium uredinicola,an Endophytic Fungus Isolated from Psidium guajava Fruits |
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| Authors: | Lívia Soman de Medeiros Michael Murgu Antônia Q L de Souza Edson Rodrigues‐Fo |
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| Institution: | 1. Departamento de Química, Universidade Federal de S?o Carlos, CEP 13.565‐905, CP 676, S?o Carlos‐SP, Brazil (phone: +55‐16‐3351?8053);2. Waters Technologies do Brasil Ltda., S?o Paulo, SP, Brazil;3. Laboratório de Produtos de Origem Microbiana – Instituto de Ciências Biológicas, Universidade Federal da Amazonas |
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| Abstract: | Four depsides, all of them new as natural products, were isolated from Cladosporium uredinicola solid‐media culture and identified as 3‐hydroxy‐2,5‐dimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 1 ), 3‐hydroxy‐2,4,5‐trimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 2 ), 3‐hydroxy‐2,5‐dimethylphenyl 3‐(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 3 ), and 3‐hydroxy‐2,4,5‐trimethylphenyl 3‐(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 4 ). The endophytic fungus was isolated from Psidium guajava fruits and cultivated over sterilized rice. The compounds 1 – 4 were purified by classical chromatographic procedures, and the chemical structures were identified by spectroscopic studies, mainly 1D‐ and 2D‐NMR and LC/ESI‐MS/MS. Three of the isolated depsides exhibited moderate bacteriostatic and/or bactericide effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtillis. |
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| Keywords: | Cladosporium uredinicola Psidium guajava Depsides Antimicrobial activity |
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