Kadsufolins A – D and Related Cytotoxic Lignans from Kadsura oblongifolia |
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| Authors: | Zehao Huang Yan Lu Yinan Liu Kenneth F. Bastow Kuohsiung Lee Daofeng Chen |
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| Affiliation: | 1. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, P.?R. China, (phone: +86‐21‐51980135;2. fax: +86‐21‐51980017);3. Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA |
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| Abstract: | Kadsufolins A–D ( 1 – 4 , resp.), four new dibenzocyclooctane‐type lignans, were isolated from the roots and stems of Kadsura oblongifolia, together with eleven known lignans. Their structures and configurations were elucidated by spectroscopic methods including 2D‐NMR techniques. The compounds were also evaluated for cytotoxic activity against human tumor cell lines A549 (lung carcinoma), DU145 (prostate carcinoma), KB (epidermoid carcinoma of the nasopharynx), and HCT‐8 (ileocecal carcinoma). Kadsufolin A ( 1 ), kadsufolin D ( 4 ), angeloylbinankadsurin A, and heteroclitin B were found to show cytotoxic activities against A549, DU145, KB and HCT‐8 with GI50 values of 5.1–20.0 μg/ml. |
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| Keywords: | Kadsura oblongifolia Lignans Dibenzocyclooctanes Cytotoxic activity Kadsufolins A – D |
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