A Facile One‐Pot Three‐Component Synthesis of 5‐(Trifluoromethyl)‐4,7‐dihydro‐[1,2,4]‐triazolo[1,5‐a]pyrimidine Derivatives in Ionic Liquid |
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| Authors: | Tuanjie Li Changsheng Yao Song Lei Chenxia Yu Shujiang Tu |
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| Affiliation: | 1. School of Chemistry and Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China;2. School of Chemistry and Engineering, Key Laboratory of Biotechnology for Medicial Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China |
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| Abstract: | An efficient one‐pot synthesis of 5‐(trifluoromethyl)‐4,7‐dihydro‐7‐aryl‐[1,2,4]triazolo[1,5‐a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3‐amino‐1,2,4‐triazole and ethyl 4,4,4‐trifluoro‐3‐oxobutanoate or 4,4,4‐trifluoro‐1‐phenylbutane‐1,3‐dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco‐friendliness. |
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| Keywords: | multicomponent reaction trifluoromethyl triazolo[1,5‐a]pyrimidine ionic liquid |
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