Selective Simultaneous Determination of Paracetamol and Uric Acid Using a Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite |
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| Authors: | Ali Babaei David J. Garrett Alison J. Downard |
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| Affiliation: | 1. Permanent address: Department of Chemistry, University of Arak, Private Bag 879, Arak 38156, Iran;2. Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand |
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| Abstract: | A multiwalled carbon nanotube/chitosan modified glassy carbon electrode (MWCNTs‐CHT/GCE) has been used for simultaneous determination of paracetamol (PAR) and uric acid (UA). The measurements were carried out using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA). DPV measurements showed a linear relationship between oxidation peak current and concentration of PAR and UA in phosphate buffer (pH 7) over the concentration range 2 µM to 250 µM, and 10 µM to 400 µM, respectively. The analytical performance of this sensor has been evaluated for detection of PAR and UA in human serum and human urine with satisfactory results. |
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| Keywords: | Paracetamol Uric acid Carbon nanotubes Chitosan Modified glassy carbon |
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