A New and Efficient Procedure for Synthesis of 1,5‐Benzodiazepine Derivatives in Solution and under Solvent‐Free Conditions |
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| Authors: | Khodayar Gholivand Karim Zare Hadi Jafari Hadi Adibi |
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| Institution: | 1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67145‐1673, Iran |
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| Abstract: | Borax/phosphorous oxychloride (BPO) efficiently catalyzes the preparation of 1,5‐benzodiazepine derivatives of o‐phenylenediamines and ketones in solvent‐free and solution conditions. The reaction proceeds efficiently under ambient conditions giving excellent yields of the products. This new protocol allows the recycling of catalyst with no loss in its potency. |
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| Keywords: | 1 5‐benzodiazepine o‐phenylenediamine borax phosphorus oxychloride |
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