Microwave‐Assisted Aqueous Synthesis: A Rapid Approach to Poly‐functionalized Indoline‐Spiro Benzofurodiazepines |
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| Authors: | Shuliang Wang Chuang Cheng Feng Gong Feiyue Wu Bo Jiang Jianfeng Zhou Shujiang Tu |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China;2. Jiangsu Key Laboratory for Chemistry of Low‐Dimensional Materials, Huaiyin Normal University, Huaian, Jiangsu 223300, China |
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| Abstract: | New cycloaddition has been established for the synthesis of indoline‐spiro benzofurodiazepine derivatives. Those reactions were conducted by reacting readily available and inexpensive starting materials, such as benzene‐1,2‐diamines, tetronic acid and indoline‐2,3‐diones, in aqueous solution under microwave irradiation. When mono‐substituted benzene‐1,2‐diamines as an amine component was employed, the reaction regioselectively resulted in the poly‐functionalized indoline‐spiro benzofurodiazepine with good yields. The present green synthesis shows attractive characteristics such as the use of water as reaction media, concise one‐pot conditions, short reaction periods, easy work‐up/purification and reduced waste production without the use of any strong acids or metal promoters. |
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| Keywords: | indoline‐spiro benzofurodiazepine microwave chemistry multicomponent reactions aqueous synthesis |
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