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Chiral Cinchona Alkaloid‐Thiourea Catalyzed Mannich Reaction for Enantioselective Synthesis of β‐Amino Ketones Bearing Benzothiazol Moiety |
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| Authors: | Peng Lin Baoan Song Pinaki S Bhadury Deyu Hu Yuping Zhang Linhong Jin Song Yang |
| Institution: | State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, Guizhou 550025, China |
| Abstract: | Mannich reactions of imine with acetylacetone were effectively catalyzed by the modified chiral cinchona alkaloid‐derived thiourea. The reactions led to chiral β‐amino carbonyl compounds in high yields and good enantioselectivities. The study demonstrated for the first time that Mannich reactions of unmodified acetylacetone with heterocyclic imine derived from benzothiazole can be promoted by chiral bifunctional organocatalyst. |
| Keywords: | asymmetric addition β ‐amino ketones Mannich reaction chiral cinchona alkaloid‐derived thiourea |