Unexpected 1,3‐Dipolar Cycloaddition Reaction of Thiazolo[3,2‐a]pyrimidine Derivatives and Nitrilimine |
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| Authors: | Xiaofang Li Haochong Liu Bin Liu Aiting Zheng Guobin Li Xianyong Yu Pinggui Yi |
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| Institution: | Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China |
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| Abstract: | The 1,3‐dipolar cycloaddition reactions of nitrilimine with thiazolo3,2‐a]pyrimidine derivatives was investigated. Bis‐cycloadducts were obtained through a domino 1,3‐dipolar cycloaddition/ring‐opening/ring‐opening/1,3‐dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X‐ray crystallographic analysis. |
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| Keywords: | 1 3‐dipolar cycloaddition thiazolo[3 2‐a]pyrimidine nitrilimine reaction mechanism synthesis |
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