Electrochemical Behaviour of the Anticancer Dacarbazine‐Cu2+ Complex and Its Analytical Applications |
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| Authors: | Yassien M. Temerk Moustafa M. Kamal Mohamed S. Ibrahim Hossieny S. M. Ibrahim Wolfgang Schuhmann |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt;2. Analytische Chemie – Elektroanalytik & Sensorik, Ruhr‐Universit?t Bochum, D‐44780 Bochum, Germany |
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| Abstract: | Electrochemical reduction of the dacarbazine‐Cu2+ complex was investigated using cyclic voltammetry and square wave voltammetry at a hanging mercury drop electrode. The reduction of the dacarbazine‐Cu2+ complex is irreversible. A reduction mechanism is proposed comprising a one‐electron reduction of the Cu2+ directly within the complex. The sharp peak of the adsorbed dacarbazine‐Cu2+ complex associated with an effective interfacial accumulation facilitates the determination of the anticancer drug dacarbazine in pharmaceutical formulations and biological fluids. Detection limits for dacarbazine of 6.12×10?10 M, 1.57×10?10 M and 1.97×10?9 M were achieved for the determination of the drug in vial, human urine and serum, respectively. |
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| Keywords: | Dacarbazine Anticancer drug Dacarbazine copper complex Voltammetry HMDE |
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