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Two New Cytotoxic Naphthoquinones from Didymocarpus hedyotideus
Authors:Xi‐Bin Xiao  Yue‐Xing Lin  Geng‐Bo Xu  Xu‐Bo Gong  Ying Gu  Jie‐Feng Tong  Jing Yang
Affiliation:1. Department of Hematology, 2nd Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, P.?R. China, (phone: +86‐571‐87783652, +86‐13858015535 (cell));2. Blood Bank, 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, P.?R. China
Abstract:A new naphthoquinone, 6‐hydroxy‐α‐dunnione ( 1 ) and a new binaphthoquinone, methyl 1,1′,4,4′‐tetrahydro‐3‐hydroxy‐1,1′,4,4′‐tetraoxo[2,2′‐binaphthalene]‐3′‐carboxylate ( 2 ), along with ten known compounds, including naphthoquinones, anthraquinones, and phenylethanoid glucosides, were isolated from the roots of Didymocarpus hedyotideus Chun . Their structures were identified by spectroscopic analyses, particularly 1D‐ and 2D‐NMR spectroscopy. The cytotoxic activities of the two new naphthoquinones were also evaluated.
Keywords:Didymocarpus hedyotideus  Naphthoquinones  α  ‐Dunnione, 6‐hydroxy‐  Binaphthoquinones  Cytotoxic activity
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