A Novel Synthesis of Isoflavones via Copper(I)‐Catalyzed Intramolecular Cyclization Reaction |
| |
| Authors: | Qiu‐Lian Li Qi‐Lun Liu Zhi‐Yuan Ge Yong‐Ming Zhu |
| |
| Institution: | 1. School of Pharmacy, Soochow University, Suzhou 215123, P.?R. China, (phone: +86‐512‐62880109;2. fax: +86‐512‐67166591) |
| |
| Abstract: | Isoflavone derivatives were synthesized via intramolecular cyclization of 3‐(2‐bromophenyl)‐3‐oxopropanal derivatives, using CuI as the catalyst, 2‐picolinic acid (=pyridine‐2‐carboxylic acid) as the ligand, K2CO3 as the base, and DMF as the solvent, in up to 96% yield. The synthesis is functional group‐tolerant. |
| |
| Keywords: | Isoflavone derivatives Copper catalysis Cyclization reactions Catalysis |
|
|
