Novel Four‐Component Approach for the Synthesis of Polyfunctionalized 1,4‐Dihydropyridines in Aqueous Media |
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| Authors: | Melika Hadjebi Mehri S Hashtroudi Hamid Reza Bijanzadeh Saeed Balalaie |
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| Institution: | 1. Peptide Chemistry Research Center, K.?N. Toosi University of Technology, P.O. Box 15875‐4416 Tehran, Iran;2. Marine Chemistry Laboratory, Iranian National Center for Oceanography (INCO), P.O. Box 14155‐4781 Tehran, Iran;3. Department of Chemistry, Tarbiat Modares University, P.O. Box 14115‐175 Tehran, Iran |
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| Abstract: | The four‐component reaction of dimethyl acetylenedicarboxylate (=dimethyl but‐2‐ynedioate; DMAD), aromatic aldehydes, and malononitrile (=propanedinitrile) leads to polyfunctionalized 1,4‐dihydropyridine derivatives. The reaction proceeds at room temperature and in the presence of a catalytic amount (20%) of (NH4)2HPO4 as a base in aqueous media. |
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| Keywords: | Pyridines 1 4‐dihydro‐ Multicomponent reactions Knoevenagel/Michael addition/cyclization reaction |
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