Synthesis of Functionalized Thiophenes by Four‐component Reactions of 1,3‐Thiazolidinedione,Aromatic Aldehydes,Cyanoacetamide and Cyclic Secondary Amines |
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| Authors: | Rong Yao Eryan Xia Jing Sun Chaoguo Yan |
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| Affiliation: | College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China |
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| Abstract: | The polysubstituted thiophene derivatives were conveniently prepared by the four‐component reactions of 1,3‐thiazolidinedione, aromatic aldehydes, cyanoacetamide and cyclic secondary amines such as pyrrolidine, morpholine and piperidine. The reaction mechanism is believed to involve domino reactions of Knoevenagel condensation, Michael addition, ring‐opening and recyclization of 1,3‐thiazolidinedione. |
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| Keywords: | multicomponent reaction domino reaction thiophene cyanoacetamide 1,3‐thiazolidinedione |
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