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In Situ Self Assembly of Thiolated ortho‐Quinone Capped Electrocatalysts for Bioanalytical Applications |
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| Authors: | Tom R Wendland Brian S Muntean Jaskiran Kaur Jhindan Mukherjee Jie Chen Xinxuan Tan Dinesh Attygalle Robert W Collins Jon R Kirchhoff L M Viranga Tillekeratne |
| Institution: | 1. Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA;2. Department of Chemistry, College of Natural Sciences and Mathematics, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA;3. Department of Physics and Astronomy, College of Natural Sciences and Mathematics, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA |
| Abstract: | Thiolated o‐quinone‐capped electrocatalysts modeled on the naturally occurring o‐quinone cofactor pyrroloquinoline quinone (PQQ) were designed and synthesized for the development of biosensor devices. The o‐quinone‐capped electrocatalysts self assembled on gold electrodes through a thiolated phenyleneethynylene linkage to form a monolayer less than 2 nm in thickness. Cyclic voltammetric measurements demonstrated reversible electrochemical properties between the quinone and hydroquinone forms of the head group. In an amperometric sensing mode, the modified electrodes reproducibly detected ethanethiol at micromolar levels demonstrating their robust electrocatalytic activity toward thiols. Their redox cycling and electrocatalytic properties show promise for detection of biologically important thiols and other nucleophiles. |
| Keywords: | Electrocatalysts Quinones Self assembly Amperometric biosensors |