Synthesis of Flavin–Calix[4]arene Conjugate Derivatives |
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| Authors: | Serkan Sayin Gülderen Uysal Akkuş Radek Cibulka Ivan Stibor Mustafa Yilmaz |
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| Affiliation: | 1. Department of Chemistry, Selcuk University, TR‐Konya‐42075, (phone: +90?332?2233873;2. fax: +90?332?2410106);3. Department of Chemistry, Afyon Kocatepe University, TR‐Afyonkarahisar‐03200;4. Department of Organic Chemistry, Institute of Chemical Technology, Technická 5 CZ‐16628‐Prague 6 |
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| Abstract: | The synthesis of two new flavin substituted calix[4]arene derivatives, 9 and 10 , is described. The first flavin substituted calix[4]arene derivative 9 was synthesized by the reaction of 3‐methylalloxazine ( 5 ) with 25,27‐bis(3‐bromopropoxy)‐26,28‐dihydroxy‐5,11,17,23‐tetra(tert‐butyl)calix[4]arene ( 4 ) in high yield (92%). The other derivative 10 was prepared from 3‐methylalloxazine‐1‐acetic acid ( 7 ) and 25,27‐bis(3‐cyanopropoxy)calix[4]arene ( 3 ). All new compounds were characterized by a combination of FT‐IR and 1H‐NMR spectroscopy, and elemental‐analysis techniques. |
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| Keywords: | Calix[4]arene Calixflavin Alloxazine |
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