A novel route to 4‐oxy/thio substituted‐1H‐pyrazol‐5(4H)‐ones via efficient cross‐Claisen condensation |
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| Authors: | R. Venkat Ragavan V. Vijayakumar |
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| Affiliation: | Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamilnadu, India |
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| Abstract: | α‐Oxy/thio substituted β‐keto esters were synthesized through an efficient cross‐Claisen condensation of oxy/thio substituted acetic acid ethyl esters with acid chlorides, which in turn converted in situ into 4‐oxy/thio substituted‐1H‐pyrazol‐5(4H)‐ones by the addition of hydrazine and its derivatives. This method has been found to be extremely fast, general, and useful toward the synthesis of inaccessible pyrazolones and synthetically demanding 4‐oxy/thio substituted pyrazolones. J. Heterocyclic Chem., (2011). |
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