Voltammetric Determination of Trace Antiepileptic Gabapentin with a Silver‐Nanoparticle Modified Multiwalled Carbon Nanotube Paste Electrode |
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Authors: | Abdollah Yari Fatemeh Papi Said Farhadi |
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Affiliation: | Department of Chemistry, Lorestan University, Flakalaflak Street 68137‐17133, Khorramabad, Iran tel./fax: +98?661?220185 |
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Abstract: | For the first time, a novel carbon nanotube bed electrode impregnated with silver–nanoparticles (AgNPs) for the determination of trace amounts of gabapentin (GBP) is described. We synthesized the AgNPs via a new procedure. The voltammetric behavior of the electrode was investigated by cyclic voltammetry. There were linear relationships in the ranges from 3.1×10?9 to 2.9×10?2 M and from 1.0×10?8 to 1.0×10?2 GBP with square wave and differential pulse voltammetric peak currents, respectively. The detection limits were 5.6×10?10 and 9.7×10?9 M, respectively. The electrode showed excellent response over a period of 2 months and was successfully applied in human plasma and pharmaceutical capsular products. |
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Keywords: | Gabapentin Differential pulse voltammetry Multiwalled nanotube Silver‐nanoparticle Square wave voltammetry |
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