New Polyketides Isolated from Botryosphaeria australis Strain ZJ12‐1A |
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| Authors: | Yu‐Hang Xu Chun‐Hua Lu Zhong‐Hui Zheng Yue‐Mao Shen |
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| Institution: | 1. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, Fujian Engineering Laboratory for Pharmaceuticals, School of Life Sciences, Xiamen University, Xiamen 361005, P.?R. China;2. Box 114, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P.?R. China (phone: +86‐531‐88382108) |
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| Abstract: | Four new polyketides, botryosphaerones A–D ( 1 – 4 , resp.), were obtained from the fermentation culture of Botryosphaeria australis strain ZJ12‐1A, together with four known compounds, O‐methylasparvenone ( 5 ), 6‐ethyl‐2,7‐dimethoxyjuglon ( 6 ) and its monoacetyl derivative 7 , and O‐methylaspmenone ( 8 ). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and HR‐Q‐TOF mass spectrometry, and by comparison with reported data. All compounds were evaluated for their cytotoxic and antimicrobial activities in vitro. Only compounds 6 and 7 showed cytotoxic and antimicrobial activities, as already reported. |
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| Keywords: | Botryosphaeria australis Polyketides Botryosphaerones A – D |
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