A New Tetracyclic Diterpene from Jatropha curcas |
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| Authors: | Jun‐Ju Xu Jun‐Ting Fan Guang‐Zhi Zeng Ning‐Hua Tan |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China (phone: +86‐871‐5223800;2. fax: +86‐871‐5223800);3. College of Tobacco Science, Yunnan Agricultural University, Kunming 650201, P.?R. China |
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| Abstract: | Jatrophodione A ( 1 ), a new diterpene with four rings, together with nine known compounds, caniojane ( 2 ), jatropholone A ( 3 ), jatropholone B ( 4 ), jatrogrossidione ( 5 ), 2‐epijatrogrossidione ( 6 ), heudelotinone ( 7 ), gossweilone ( 8 ), (3α)‐3‐hydroxy‐ent‐pimara‐8(14),15‐dien‐12‐one ( 9 ), and 12‐hydroxy‐13‐methylpodocarpa‐8,11,13‐trien‐3‐one ( 10 ), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9 , and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D‐NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8 , and 9 were tested on the three cancer cell lines A549, Hela, and SMMC‐7721. Results showed that 7 exhibited cytotoxicity against SMMC‐7721 with an IC50 value of 21.68 μM , whereas 7 and 8 were active against A549 with the IC50 values of 16.04 and 20.47 μM , and against Hela with the IC50 values of 10.67 and 22.83 μM , respectively. |
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| Keywords: | Jatropha curcas Jatrophodione A Diterpenes tetracyclic Cytotoxic activity |
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