Sesquiterpenoids from the Aerial Parts of Inula japonica |
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| Authors: | Hai‐Qun Gong Quan‐Xiang Wu Lei‐Lei Liu Jun‐Li Yang Rui Wang Yan‐Ping Shi |
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| Institution: | 1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.?R. China (phone: +86‐931‐4968208;2. fax: +86‐931‐8277088);3. Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.?R. China |
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| Abstract: | Fourteen sesquiterpenoids with an eudesmane C‐atom skeleton, including four new ones, (1β,5α,7β,8β,11β)‐5‐hydroperoxy‐1‐hydroxyeudesm‐4(15)‐eno‐12,8‐lactone ( 1 ), (1β,5α,7β,8β)‐8‐(acetyloxy)‐5‐hydroperoxy‐1‐hydroxycostic acid methyl ester ( 12 ), and a mixture of (1β,3β,4β,7β,8β)‐1,3‐dihydroxyeudesma‐5,11(13)‐dieno‐12,8‐lactone ( 7 ) and (1β,3β,4β,7β,8β,11β)‐1,3‐dihydroxyeudesm‐5‐eno‐12,8‐lactone ( 8 ), were isolated from the aerial parts of Inula japonica (Asteraceae). Their structures were determined by extensive spectroscopic methods, and those of 7 and 12 confirmed by means of single‐crystal X‐ray diffraction analysis. |
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| Keywords: | Inula japonica Sesquiterpenoids Eudesmanes X‐Ray crystallography |
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