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Facile Synthesis of Substituted Ethyl 2‐(Chloromethyl)‐2‐hydroxy‐2H‐1‐benzopyran‐3‐carboxylates |
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| Authors: | Bhimapaka China Raju Gannerla Saidachary Jaladi Ashok Kumar Balasubramanian Sridhar |
| Institution: | 1. Organic Chemistry Division‐1, Indian Institute of Chemical Technology, Hyderabad‐500 607, India, (phone: +914027161725;2. fax: +91402716512);3. Laboratory of X‐Ray Crystallography, Indian Institute of Chemical Technology, Hyderabad‐500 607, India |
| Abstract: | Ethyl 2‐(chloromethyl)‐2‐hydroxy‐2H‐chromene‐3‐carboxylates 2a – 2j have been synthesized by reaction of substituted salicylaldehydes with ethyl 4‐chloro‐3‐oxobutanoate, in the presence of piperidine in CH2Cl2 at room temperature, in good yields. |
| Keywords: | 2H‐1‐Benzopyran‐3‐carboxylates 2H‐Chromene‐3‐carboxylates ethyl 2‐(chloromethyl)‐2‐hydroxy‐ Salicylaldehydes Butanoate ethyl 4‐chloro‐3‐oxo‐ Knoevenagel condensations |