Flavone 8‐C‐Glycosides from Haberlea rhodopensis Friv. (Gesneriaceae) |
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| Authors: | Samad N. Ebrahimi Frank Gafner Giorgio Dell'Acqua Kuno Schweikert Matthias Hamburger |
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| Affiliation: | 1. Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH‐4056 Basel, (phone: +41‐61‐267?14?25;2. fax: +41‐61‐267?14?74);3. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Tehran, Iran;4. Induchem AG, Industriestrasse 8a, CH‐8604 Volketswil |
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| Abstract: | Phytochemical profiling of a MeOH extract from Haberlea rhodopensis by a combination of liquid/liquid extraction, and preparative and semi‐preparative HPLC afforded three new flavone C‐glycosides, hispidulin‐8‐C‐(2″‐O‐syringoyl)‐β‐glucopyranoside ( 3 ), hispidulin 8‐C‐(6‐O‐acetyl‐β‐glucopyranoside) ( 4 ), and hispidulin 8‐C‐(6‐O‐acetyl‐2‐O‐syringoyl‐β‐glucopyranoside) ( 5 ), along with two known phenolic glycosides, myconoside ( 1 ) and paucifloside ( 2 ). The structures were established by extensive spectroscopic analyses including 1D‐ and 2D‐NMR (COSY, HSQC, and HMBC), and HR‐ESI‐TOF‐MS, and by comparison with published data. |
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| Keywords: | Haberlea rhodopensis Glycosides Gesneriaceae Flavone C‐glucosides |
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