Diverse meta‐C−H Functionalization of Arenes across Different Linker Lengths |
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| Authors: | Dr Ramasamy Jayarajan Jayabrata Das Sukdev Bag Rajdip Chowdhury Prof?Dr Debabrata Maiti |
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| Institution: | 1. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai-, India;2. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, India |
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| Abstract: | Arenes containing conformationally flexible long alkyl chains have been successfully functionalized at the meta‐position. Good to excellent meta selectivity is achieved for systems with up to 20 atoms between the target C?H bond and the coordinating heteroatom of the directing group. The palladium‐catalyzed functionalization reactions include alkylation, cyanation, olefination, and acetoxylation. The meta selectivity is exclusively governed by the design of flexible pyrimidine‐based scaffolds. |
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| Keywords: | arenes C− H activation conformational flexibility palladium synthetic methods |
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