|
|||||
|
|
More Than 12 % Polarization and 20 Minute Lifetime of 15N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water |
|
| Authors: | Jeffrey McCormick Dr Sergey Korchak Dr Salvatore Mamone Dr Yavuz N Ertas Zhiyu Liu Luke Verlinsky Dr Shawn Wagner Dr Stefan Glöggler Prof Louis‐S Bouchard |
| Institution: | 1. Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA, USA;2. Research Group for NMR Signal Enhancement, Max Planck Institute for Biophysical Chemistry, G?ttingen, Germany;3. Center for Biostructural Imaging of Neurodegeneration, G?ttingen, Germany;4. Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, USA;5. Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;6. The Molecular Biology Institute, Jonsson Comprehensive Cancer Center, California NanoSystems Institute, University of California at Los Angeles, USA |
| Abstract: | Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand‐stabilized Rh catalyst is introduced that is capable of achieving 15N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin‐lattice relaxation time (T1) of 21.0±0.4 min. These results open the door to the possibility of 15N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen‐induced polarization (PHIP) as the hyperpolarization method. |
| Keywords: | heterogeneous catalysis hyperpolarization parahydrogen-induced polarization polarization transfer rhodium nanoparticles |