Electro‐Oxidative S−H/S−H Cross‐Coupling with Hydrogen Evolution: Facile Access to Unsymmetrical Disulfides |
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| Authors: | Pengfei Huang Pan Wang Shan Tang Zhuangjiong Fu Prof Aiwen Lei |
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| Institution: | 1. http://aiwenlei.whu.edu.cn/lawsys/;2. Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China;3. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, P. R. China |
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| Abstract: | Sulfur is an essential element because it exists widely in proteins. The disulfide bond is an important moiety in many different types of significant organic molecules. A new approach for oxidant‐ and catalyst‐free S?H/S?H cross‐coupling, with hydrogen evolution, to construct unsymmetrical disulfides was developed. Under the conditions of an undivided cell at room temperature, a series of unsymmetrical disulfides were prepared with up to 87 % yield from the direct coupling of an aryl mercaptan and alkyl mercaptan. Gram‐scale synthesis also highlights the synthetic utility of this electrochemical strategy. |
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| Keywords: | cross-coupling electrochemistry hydrogen mercaptans synthetic methods |
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