Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex |
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| Authors: | Congreve Aileen Parker David Gianolio Eliana Botta Mauro |
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| Institution: | Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK. |
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| Abstract: | Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex LnL1], bearing an N-linked CH2CH2NHCO-pyridyl moiety, forms mono-aqua (q = 1) species in solution and the Gd complex undergoes rapid water exchange (k(ex)= 11 x 10(7) s(-1), 298 K) as a result of the steric destabilisation of the Ln-water binding interaction. The homologous complex with a C-3 spacing chain, LnL2], forms a q = 0 species. |
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