Institution: | aUniversità degli Studi di Salerno, Dipartimento di Scienze Farmaceutiche, Via Ponte don Melillo, 84084 Fisciano (SA), Italy bUniversità degli Studi di Napoli Federico II, Dipartimento di Patologia e Sanità Animale, Sezione di Tossicologia, Napoli, Italy |
Abstract: | Two new sulfated cadinene-type sesquiterpene glycosides, 13-hydroxy-7-O-(6′-O-sulfate-β-d-glucopyranosyl)-desoxyhemigossypol (1) and 13,15-dihydroxy-7-O-(6′-O-sulfate-β-d-glucopyranosyl)-desoxyhemigossypol (2), have been isolated from whole cottonseed (Gossypium hirsutum). Their structures, which possess an unusual 6-O-sulfate-glucopyranosyl moiety, were determined through the interpretation of 2D NMR spectral data and H/D exchange ESI-MS experiments. Compounds 1 and 2 were screened for their toxicity on Jurkat cells. Both compounds inhibited cellular proliferation with IC50 values of 8.1 and 4.2 μg, respectively. |