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Highly stereoselective one-pot synthesis of tetrasubstituted alkenes via carbopalladation reaction of fluorine-containing acetylene derivatives |
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| Authors: | Tsutomu Konno Ken-ichi Taku Takashi Ishihara |
| Affiliation: | Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan |
| Abstract: | Treatment of fluoroalkylated alkynes with various aryl halides and arylboronic acids in the presence of Pd(0) in DMF/H2O at 100 °C for 2 h led to the smooth three-component coupling reaction, the corresponding tetrasubstituted alkenes being obtained in high yields stereoselectively. |
| Keywords: | A fluoroalkyl group Carbopalladation One-pot reaction Tetrasubstituted alkenes Fluorine-containing alkynes |
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