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Simple and convenient synthesis of 3,5-bis-(trifluoromethyl)benzylamine via biomimetic 1,3-proton shift reaction |
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| Authors: | Vadim A Soloshonok Manabu Yasumoto |
| Institution: | Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA |
| Abstract: | This paper describes an efficient, practical synthesis of 3,5-bis(trifluoromethyl)benzylamine via biomimetic transamination of 3,5-bis(trifluoromethyl)benzaldehyde with benzylamine. From a synthetic standpoint the reported procedure is highly operationally convenient and scalable as it does not require any chromatographic purification of the intermediate products. |
| Keywords: | 1 3-Proton shift reaction Fluorine and compounds Imines Operationally convenient conditions Biomimetic reductive methodology |
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