Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review |
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Authors: | Mansour Mohamadzadeh and Ronald Luftig |
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Institution: | (1) Department of Medicine, Tulane University Health Science Center, New Orleans, USA;(2) Department of Microbiology, Immunology and Parasitology, Louisiana State University, New Orleans, USA |
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Abstract: | Dendritic cellls (DCs) comprise an essential component of the immune system. These cells, as antigen presenting cells (APCs)
to na?ve T cells, are crucial in the initiation of antigen specific immune responses. In the past years, several DC subsets
have been identified in different organs which exert different effects in order to elicit adaptive immune responses. Thus,
identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this
review, several key properties of the immunobiology, immunopathogenesis and vaccine strategies using DCs will be discussed. |
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