Fluorine-18 and medical imaging: Radiopharmaceuticals for positron emission tomography |
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Authors: | Didier Le Bars |
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Affiliation: | UMR 5181 Université de Lyon, Cermep Imagerie du Vivant, 59 Boulevard Pinel, 69677 Bron, France |
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Abstract: | Fluorine presents among its radioactive isotopes fluorine-18, that decays with a 109 min half-life and a β+ emission, allowing external detection of the two coincident γ photons obtained after annihilation. Production techniques (medical cyclotron), radiochemical reactions for isotope incorporation in radiopharmaceuticals and development of specific detection cameras (positron emission tomographs) allowed development of a vast investigation field in medical imaging.Applications of PET in oncology ([18F]fluorodeoxyglucose, FDG) largely improved detection and management of cancers; tracer molecules labelled with fluorine-18 also allow fruitful researches in molecular imaging. |
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Keywords: | Fluorine-18 Radiopharmaceuticals Labelled compounds Positron emission tomography |
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