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One-pot synthesis of N-protected α-amino aldehyde acetals from three-component reaction of fluoroalkanesulfonyl azide, vinyl ether and alcohol |
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| Authors: | Chaoyue Qin Shizheng Zhu Song Cao |
| Affiliation: | a Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, P.O. Box 544, 130 Meilong Road, Shanghai 200237, China b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China |
| Abstract: | A facile one-step method has been developed for the synthesis of N-protected α-amino aldehyde acetals in moderate to good yields by three-component reaction of fluoroalkanesulfonyl azides, vinyl ethers and alcohol at 0 °C within 10 min. This practical synthetic method provides a convenient and expeditious access to N-per(poly)fluoroalkanesulfonyl α-amino aldehyde acetals. |
| Keywords: | Fluoroalkanesulfonyl azide Vinyl ether Alcohol α-Amino aldehyde acetals Multi-component reactions (MCRs) |
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