Selective aliphatic fluorination by halogen exchange in mild conditions |
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Authors: | Laurent Saint-Jalmes |
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Institution: | Rhodia Recherche et Technologie, Centre de Recherche de Lyon, 85 Avenue des Frères Perret, 69192 Saint-Fons Cedex, France |
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Abstract: | HF-Base media, in particular (HF)10-pyridine or (HF)3-triethylamine, allow aliphatic chlorine-fluorine exchanges on acid-sensitive molecules. Depending on the nature (pyridine or triethylamine), stoichiometry of the base and temperature, selective mono-, di-, or tri-chlorine-fluorine exchanges on trichloromethyl groups alpha to sulfur, oxygen and carbon atoms can be obtained. |
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Keywords: | Selective aliphatic chlorine-fluorine exchange HF-Base (HF)10-pyridine (HF)3-triethylamine |
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