A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions |
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| Authors: | Lu Bruce Z Zhao Wenyi Wei Han-Xun Dufour Marine Farina Vittorio Senanayake Chris H |
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| Institution: | Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., Suite 205, East Leigh Street, Richmond, Virginia 23219, USA. zlu@rdg.boehringer-ingelheim.com |
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| Abstract: | Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination. |
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