Oxazaborolidines as functional monomers: ketone reduction using polymer-supported Corey,Bakshi, and Shibata catalysts |
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Authors: | Price Michael D Sui Jennifer K Kurth Mark J Schore Neil E |
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Institution: | Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA. |
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Abstract: | The first two polymer-supported versions of the Corey, Bakshi, and Shibata (CBS) catalyst have been prepared. Functional monomers based structurally upon the original B-methylated catalyst have been used to prepare catalytic polymers containing the CBS moiety bound both in a pendant fashion and in the form of a cross-link. Enantioselective reductions of two prochiral ketones have been carried out using the original catalyst in the solution phase as well as the two solid-state systems. While the pendant-bound system shows reduced stereoselectivity, the cross-linked version affords enantioselectivities almost identical to those of the solution-phase model. |
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