Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization |
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| Authors: | Zhang Dun Xing Xuechao Cuny Gregory D |
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| Institution: | Department of Chemical & Biological Engineering, Tufts University, Science and Technology Center, 4 Colby Street, Medford, Massachusetts 02155, USA. |
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| Abstract: | A method for the preparation of enantiomerically pure hydantoins from optically pure alpha-amino amides utilizing triphosgene is described. We also propose that the racemization observed with 1,1'-carbonyldiimidazole (CDI) for this type of reaction is due to the imidazole carbamate intermediates. |
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