Stereoselective synthesis of the rocaglamide skeleton via a silyl vinylketene formation/[4 + 1] annulation sequence |
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| Authors: | Giese Matthew W Moser William H |
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| Institution: | Department of Chemistry and Chemical Biology, Indiana University-Purdue University, Indianapolis, Indiana 46202, USA. |
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| Abstract: | The tricyclic core of the cyclopentabenzofurans has been prepared in an efficient and stereoselective manner utilizing an intramolecular silyl vinylketene formation/4 + 1] annulation sequence. This novel approach affords the ABC ring system where the adjacent phenyl and aryl substituents of the C ring have the required cis relationship. |
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