Study of the stability of pyrimidine series cytostatics,ftorafur and fluorouracil injections

The stability of the cytostatics, ftorafur and fluorouracil injections, was studied in dependence on irradiation with UV light and on the medium temperature and pH. In the first stage of the thermal and photochemical decomposition of ftorafur, tetrahydrofuran dissociated from position N₁ in the pyrimidine ring and 5-fluorouracil was formed. In the second stage of the thermal and photochemical decomposition of ftorafur, the pyrimidine ring opened between N₃ and C₄ and between C₆ and N₁, with formation of urea. Ftorafur, fluorouracil, and urea were determined using thin-layer chromatography and spectrophotometry in the UV and visible region.