Study of the stability of pyrimidine series cytostatics,ftorafur and fluorouracil injections |
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| Authors: | Hana Tománková Jaroslav Zýka |
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| Institution: | 1. Institute for Control of Drugs, Prague, Czechoslovakia;2. Department of Analytical Chemistry, Charles University, Prague, Czechoslovakia |
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| Abstract: | The stability of the cytostatics, ftorafur and fluorouracil injections, was studied in dependence on irradiation with UV light and on the medium temperature and pH. In the first stage of the thermal and photochemical decomposition of ftorafur, tetrahydrofuran dissociated from position N1 in the pyrimidine ring and 5-fluorouracil was formed. In the second stage of the thermal and photochemical decomposition of ftorafur, the pyrimidine ring opened between N3 and C4 and between C6 and N1, with formation of urea. Ftorafur, fluorouracil, and urea were determined using thin-layer chromatography and spectrophotometry in the UV and visible region. |
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