| Abstract: | Detailed knowledge of enzyme mechanisms has previously led to the design of „enzyme mimetics”︁, small synthetic compounds that use the same principles of catalysis as enzymes but need a less complicated framework than proteins. The development of enzyme mimetics for the hydrolysis of RNA is of special interest because of their potential use as drugs in gene therapy. Field development from the first active compounds discovered in the late 80s to the application of highly specific artificial RNases in vitro is described. |
