Marine cytotoxic macrolides haterumalides and biselides, and related natural products |
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| Authors: | Kigoshi Hideo Hayakawa Ichiro |
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| Institution: | Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan. kigoshi@chem.tsukuba.ac.jp |
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| Abstract: | Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products. |
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| Keywords: | marine cytotoxic macrolide haterumalides biselides human cancer cell lines |
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