DNA-mediated charge transport by minor groove-binding polyamide |
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| Institution: | 1. Beijing National Laboratory for Molecular Sciences, Institute of Physical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China;2. Department of Chemical Biology, The Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Peking University, Beijing 100871, PR China;1. Laboratoire de Réactivité et Chimie des Solides and ALISTORE European Research Institute, UMR CNRS 7314, UFR des Sciences, 33 rue Saint Leu, 80039 Amiens cedex, France;2. CIRIMAT/LCMIE and ALISTORE European Research Institute, UMR CNRS 5085, 31062 Toulouse cedex 9 - France;1. Materials Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, 416004, (M.S.), India;2. Thin Film Materials Laboratory, Department of Physics, Shivaji University, Kolhapur, 416004, (M.S.), India;3. Chemistry Division, Bhabha Atomic Research Centre (BARC), Mumbai, India;4. School of Applied Chemical Engineering, Chonnam National University, Gwangju, 500-757 (South Korea);5. Fluorescence spectroscopy laboratory, Department of Physics, Shivaji University, Kolhapur, 416004, (M.S.), India;6. Photonic and Electronic Thin Film Laboratory, Department of Materials Science and Engineering, Chonnam National University, Gwangju 500-757, South Korea;1. College of Textile, Tianjin Polytechnic University, Tianjin 300387, PR China;2. Key Laboratory of Advanced Textile Composite Materials of Ministry of Education, Tianjin Polytechnic University, Tianjin 300387, PR China;3. Yanshan University, Qinhuangdao 066004, PR China;1. Department of Physics, Sharif University of Technology, P.O. Box 11365-9567, Tehran, Iran;2. Department of Physics, Faculty of Basic Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran;3. Research and Development Department, Darou Pakhsh Pharmaceutical Mfg. Co., Tehran, Iran;1. Laboratory of Microbial Ecology and Technology, Biocatalysis and Industrial Enzymes Group, Carthage University, National Institute of Applied Sciences and Technology (INSAT), BP 676, 1080 Tunis Cedex, Tunisia;2. Mass Spectrometry Laboratory/Organic Pollutants, IDAEA-CSIC, Jordi Girona, 18-26, 08034 Barcelona, Spain;3. Food Science and Nutrition Department, INSA, XaRTA (Catalonian Reference Network on FoodTechnology), University of Barcelona, Food and Nutrition Torribera Campus, Av. Prat de la Riba, 171, 08921 Santa Coloma de Gramenet, Spain;3. Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, The University of Vermont, Burlington, Vermont 05405-0068;4. Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850 |
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| Abstract: | A novel polyamide-modified electrode was fabricated successfully by surface synthesis. The DNA-mediated charge transport by minor groove-binding polyamide was observed for the first time with a Ru(NH3)6]2+/3+ probe. Two control experiments on HSC11H22NH2 SAM/Au electrode, with and without DNA adsorption, confirmed that polyamide–DNA complex was a medium of charge transport. Four different DNA sequences were employed to investigate the effect of the charge transport of the polyamide–DNA complex in the minor groove. The peak current and a positive shift of peak potential were enhanced with the affinity increase between polyamide and DNA sequences. The experimental result offers a powerful tool for exquisite recognition of different sequences of base-pairs in double-stranded DNA. |
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