The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode |
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| Affiliation: | 1. Department of Chemistry and Physics, Universidad del Turabo, Gurabo 00778, Puerto Rico;2. Department of Chemistry, P.O. Box 23346, University of Puerto Rico, Río Piedras Campus, San Juan 00931-3346, Puerto Rico;1. Institute of Environmental and Chemical Engineering, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice CZ-532 10, Czech Republic;2. Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice CZ-532 10, Czech Republic;3. Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Ilkovičova 3, Bratislava SK-812 19, Slovak Republic |
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| Abstract: | The aim of the present study was the qualitative determination of the pure clarithromycin using a gold electrode in neutral electrolyte by cyclic linear sweep voltammetry. It was shown that in the range of −1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO3, a gold electrode is successfully employed for the qualitative determination of clarithromycin by detection of the reproductive four anodic and one cathodic peaks. After the potentiostatic measurements at the potential values corresponded to current peaks, the bulk electrolyte was analyzed by FTIR spectroscopy to show the changes in molecular structure of clarithromycin. FTIR analysis of the bulk electrolyte after 4 h of holding the potential at −0.61 V vs. SCE (cathodic peak) showed the apparent changes in clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. |
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