Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity |
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| Authors: | Li-Gen Lin Henry Pak-Ho Leung Jian-Yu Zhu Chun-Ping Tang Chang-Qiang Ke John A Rudd Ge Lin Yang Ye |
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| Institution: | aState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China;bDepartment of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, PR China;cShanghai Institute of Technology, 120 Chao-Bao Road, Shanghai 200235, PR China |
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| Abstract: | Three new croomine-type Stemona alkaloids, tuberocrooline (1), 10-hydroxycroomine (2), and dehydrocroomine (3), and four new tuberostemonine-type alkaloids, tuberostemoline (4), tridehydrotuberostemonine (5), 9α-bisdehydrotuberostemonine (6), and 9α-bisdehydrotuberostemonine A (7), along with ten known constituents, were isolated from the roots of Stemona tuberosa collected from Yunnan province. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectra and other spectroscopic studies. The antitussive activity of the major alkaloids was tested using the citric acid-induced guinea pig cough model. Croomine (8) exhibited a dose-dependent inhibition of coughing with an ID50 value of 0.18 mmol/kg. |
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| Keywords: | Stemona tuberosa Croomine-type alkaloids Tuberostemonine-type alkaloids Antitussive Croomine |
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