| 海洋放线菌Streptomyces sp.124092中的细胞毒活性成分 |
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| 引用本文： | 解修超,梅文莉,曾艳波,林海鹏,庄令,戴好富,洪葵. 海洋放线菌Streptomyces sp.124092中的细胞毒活性成分[J]. 高等学校化学学报, 2008, 29(11): 2183-2186 |
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| 作者姓名： | 解修超 梅文莉 曾艳波 林海鹏 庄令 戴好富 洪葵 |
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| 作者单位： | 中国热带农业科学院热带生物技术研究所,海口,571101;陕西理工学院陕西省资源生物重点实验室,汉中,723001;中国热带农业科学院热带生物技术研究所,海口,571101 |
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| 基金项目： | 国家重点基础研究发展规划(973计划) ， 科研院所社会公益研究专项基金 |
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| 摘 要： | 对海洋放线菌Streptomyces sp.发酵液的提取物进行柱层析分离, 得到5个化合物. 经MS, NMR, 1H-1H COSY, HSQC和HMBC等数据鉴定, 其结构分别为3-氨基-丙酸对甲苯酯(1)、6-Amino-3-(4-hydroxybenzyl)-1,4-diazonane-2,5-dione(2)、正丁基-α-D-吡喃甘露糖苷(3)、大豆苷元(4)和1H-3-吲哚甲酸(5). 其中化合物1和2为新化合物, 细胞毒活性测试结果表明, 化合物1~4对人肝癌细胞(SMMC-7721)具有不同程度的生长抑制活性.
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| 关 键 词： | 海洋放线菌 Streptomyces sp 细胞毒活性 分离和纯化 |
| 收稿时间： | 2008-03-03 |
Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092 |
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| XIE Xiu-Chao,MEI Wen-Li,ZENG Yan-Bo,LIN Hai-Peng,ZHUANG Ling,DAI Hao-Fu,HONG Kui. Cytotoxic Constituents from Marine Actinomycete Streptomyces sp. 124092[J]. Chemical Research In Chinese Universities, 2008, 29(11): 2183-2186 |
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| Authors: | XIE Xiu-Chao MEI Wen-Li ZENG Yan-Bo LIN Hai-Peng ZHUANG Ling DAI Hao-Fu HONG Kui |
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| Affiliation: | Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; Shanxi Key Laboratory of Resource Biology, Shanxi University of Technology, Hanzhong 723001, China |
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| Abstract: | To study the cytotoxic constituents from marine actinomycete Streptomyces sp.(124092) of rhizosphere soil of mangrove plant Heritiera littoralis, five compounds were isolated by column chromatography from the fermentation broth of marine actinomycete Streptomyces sp.(124092). Their structures were elucidated as p-tolyl 3-aminopropanoate(1), 6-amino-3-(4-hydroxybenzyl)-1,4-diazonane-2,5-dione(2), n-butyl mannoside(3), daidzein(4), and indole-β-carboxylic acid(5), by MS, NMR, 1H-1H COSY, HMQC, and HMBC spectra. Among them, compounds 1 and 2 are new compounds. Cytotoxic bioassay results show that compounds 1—4 possess inhibitory effects on human hepatoma SMMC-7721 cell line in vitro. |
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| Keywords: | Streptomyces sp |
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